Postural Orthostatic Tachycardia Syndrome is quite a debilitating condition that affects teenagers and young adults. Sometimes it is mild, however in some cases symptoms are very severe and refractory to medical treatment. This case report describes a young girl with severe symptoms who had dramatic improvement using the Biotronik Closed Loop System.pots-paper
This is a great review paper by Jon Skinner in New Zealand. He divides SIDS into 4 groups.
- Patients who had had SIDS completely unrelated to any genetic channelopathy. This is by far the most common group
- Patients who have genetic polymorphisms in SCN5A, that confers some predisposition
- Patients who actually have long QT syndrome
- Patients who have the most server forms of channelopathy, often dying in utero or soon after birth from ventricular fibrillation
This paper and statement puts early repolarization into perspective. “This is perhaps best illustrated by borrowing an example from the named authors: the risk of idiopathic VF in individuals aged <45 years is ≈3/100 000 per year.10 This risk increases to 11/100 000 when J waves are present on ECG and to 30/100 000 in individuals with the ER pattern currently associated with the highest risk (inferolateral J waves followed by a horizontal or downsloping ST segment).”